According to current studies, low testosterone in men is strongly linked with metabolic syndrome, cardiovascular disease, type-II diabetes and 50% lift up in mortality. The study conducted in matured, obese male resulted in an augment in insulin sensitivity, decrease in total cholesterol, waist circumference, fat mass and pro-inflammatory cytokines linked with diabetes, metabolic syndrome and atherosclerosis.
Hormone therapy significantly enhances erectile function and even the ability to conduct physical activity without harsh pressure in men suffering from heart failure.
Factors Affecting Male Testosterone Levels
DHEA – Determines the level of testosterone and estrogen
Aromatase – Aromatase enzyme changes testosterone to estrogen. This depletes free testosterone level, increasing estrogen intensity.
Obesity – The action of LH (luteinizing hormone) in testes is suppressed due to fatness linked with hyperinsulinemia. Thus, circulating testosterone reduces significantly even in males under 40 years. Increase in abdominal fat leads to increase in aromatase activity.
SHBG (sex hormone-binding globulin) – The testosterone circulating in blood is united with 60% SHBG, 38% albumin and 2% is free or unbound. Aging men experience increase in SHBG production and aromatase activity, these results in total as well as free testosterone levels. The balance of this skewed ratio is essential for men’s health.
The precise cause of age-related decline in testosterone is still unknown. It may be due to the combination of above factors.
Consequences of Decrease in Testosterone Levels
Testosterone affects the fat cell metabolism
Lipoprotein lipase needed for avoiding the absorption of lipid gets blocked
Increases insulin sensitivity
Enhances muscle fibers growth
Decreases fat deposits
This process promotes lean body mass as well as cuts fat mass. It even suggests that maintaining young-adult testosterone levels may aid-growing men avoid an array of inflammation-mediated disease like arthritis, atherosclerosis, asthma, bronchitis, diabetes, and cardiovascular disease.
Muscuoskeletal system – Testosterone and estrogen levels control bone formation and resorption. Testosterone supplementation positively affects muscle metabolism & strength, which lessens with age.
CNS (central nervous system) – Low testosterone levels is related to depression and psychological disorders. In aging men, it can be due to many antidepressant medicines that can suppress libido.
HRT reduces the need for antidepressant medications and increases the feeling of well-being. Cognition and alertness governed by CNS gets affected.
Testosterone acts as neuro-protective agent and supports against different toxic insults like oxidative stress. It also influences the possibility of Alzheimer’s disease.
Metabolism of glucose & lipid – Male displaying low testosterone are twice insulin resistant in comparison to people with normal levels. Male suffering from diabetes has low T than their equivalent not diabetic.
Cardiovascular health – research points that low T level is correlated with quite a few cardiovascular risk factors like insulin resistance, atherogenic lipid, propensity to clot and obesity.
Prostate health – Old men have extreme estradiol circulating in comparison to free testosterone fraction. This rise in estrogen and decrease in androgen levels sharply affect prostate glands. With age, estrogen level rises considerably in the prostate, but escalates a lot in those males, who have BPH.
Use Hormone Replacement Therapy Wisely
HRT must not be commenced without comprehensive testing
The tends and patterns overtime on multiple hormone levels help to determine the need of particular hormone replacement
Testosterone dosage must be used with aromatase inhibiting supplements
Careful screening is needed to avoid worsening of prostate cancer
You must work on HRT closely with a specialized doctor and plan rational treatment approach
Jackie Conrad is an expert on men’s health, and he works with one of the most reputed hormone therapy centers in Denver. They help their clients in curing various health disorders that start coming in after the mid thirties. For more information, visit their website.